Carolina Geranium prefers consistently moist but well-drained soil, especially during its active growth phase in spring and early summer. It can tolerate some drought once established, but regular watering will promote healthier growth and more abundant flowering. Avoid overwatering, which can lead to root rot, particularly in heavy soils.

Pruning is generally minimal for Carolina Geranium, given its annual or biennial nature. The primary reason to prune would be deadheading spent flowers, which can encourage a slightly longer blooming period and prevent the plant from self-seeding too aggressively if desired. Light trimming can also be performed to maintain a neater appearance, though it's often appreciated for its natural, somewhat wild growth habit.

Carolina Geranium is most easily propagated by seed. The plant produces distinctive "cranesbill" seed capsules that mature and dry, releasing seeds. These seeds can be collected and sown directly into the garden in late summer or early autumn, where they will typically germinate the following spring. It is a prolific self-seeder, often spreading naturally throughout suitable garden areas without intervention.

Repotting is not a typical care requirement for Carolina Geranium, as it is an annual or biennial plant that completes its life cycle within one or two growing seasons. If grown in containers, it is usually treated as a seasonal plant, started fresh from seed each year. There is no need to transplant or repot an established plant, as it will naturally senesce after flowering and setting seed.