Diaperia prolifera, commonly known as flathead rabbit tobacco, is a herbaceous perennial native to the southeastern United States. This species belongs to the Asteraceae family, a large and diverse group of flowering plants that includes daisies and sunflowers. Flathead rabbit tobacco is recognized for its distinctive inflorescences and its role within its native ecosystems. The plant typically grows to a height of 30 to 60 centimeters, forming clumps of erect stems. Its leaves are alternate, sessile, and linear to narrowly lanceolate, measuring approximately 2 to 5 centimeters in length. The leaf margins are entire, and the surfaces are generally glabrous or sparsely pubescent. The most striking feature of Diaperia prolifera is its capitula, or flower heads. These are arranged in a corymbose or paniculate inflorescence at the apex of the stems. Each capitulum is relatively small, measuring about 5 to 8 millimeters in diameter, and is composed of numerous small, tubular florets. The ray florets are absent, and the disc florets are typically white or cream-colored, giving the inflorescence a somewhat flattened, or "flathead," appearance. The fruit is an achene, a small, dry, indehiscent fruit, which is characteristic of the Asteraceae family. Diaperia prolifera is found in sandy soils, pine savannas, open woodlands, and disturbed areas across a range that includes states from the Carolinas south to Florida and west to Texas. It thrives in full sun to partial shade and prefers well-drained soils. While it is adapted to relatively dry conditions, it can also tolerate moist sites. Its native habitat often includes areas with sandy or loamy substrates, frequently associated with longleaf pine ecosystems. Cultivation requirements are generally minimal for this adaptable native, favoring well-drained soils and open to partially shaded exposures. Ecologically, flathead rabbit tobacco serves as a food source for certain insects and provides habitat for small wildlife. Its flowers attract pollinators, contributing to the biodiversity of its native environment. While not widely cultivated for ornamental purposes, its unique inflorescence and native status make it of interest to those seeking to establish naturalistic landscapes or support local ecosystems. There is no significant documented use in medicinal, culinary, or economic applications for Diaperia prolifera. An interesting characteristic of Diaperia prolifera is its common name, "rabbit tobacco," which is shared with other species in the Gnaphalium genus and related genera. This name likely refers to the soft, woolly texture of the leaves or perhaps to historical uses of related plants. The specific epithet "prolifera" refers to the production of new shoots or branches, a growth habit that contributes to its clumping form. The plant's ability to thrive in nutrient-poor, sandy soils highlights its adaptation to specific ecological niches within the southeastern United States.